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Menetrier's disease

Etiology: unknown Epidemiology: - rare, acquired - adult & pediatric forms [3] Pathology: 1) gastric mucosal hypertrophy 2) pseudopolypoid, thickened rugal folds 3) protein-losing gastropathy 4) hypoalbuminemia 5) gastric pit region (foveolar) hyperplasia Clinical manifestations: 1) abdominal pain, especially after eating 2) nausea/vomiting 3) hematemesis Laboratory: - serum albumin low - urinalysis: no proteinuria - liver function tests unremarkable Special laboratory: -> gastrointestinal endoscopy with tissue biopsy Radiology: - CT of abdomen - Scintigraphy with technetium-99m-labeled albumin reveals gastrointestinal protein loss Management: 1) proton pump inhibitor or other antacid 2) high-protein diet 3) partial gastrectomy may be necessary to control symptoms 4) case presentation in 5 year old boy with resolution of symptoms after 4 months

General

gastritis

References

  1. Saunders Manual of Medical Practice, Rakel (ed), WB Saunders, Philadelphia, 1996, pg 327
  2. Akita C, Saikawa Y. (images) Gastric Gyri - Pediatric Menetrier's Disease. N Engl J Med 2017; 376:774February 23, 2017 PMID: 28225680 http://www.nejm.org/doi/full/10.1056/NEJMicm1605473
  3. NIDDK: Menetrier's Disease https://www.niddk.nih.gov/health-information/digestive-diseases/menetriers-disease